Alphinity seeks to avoid companies that are involved in activities that it considers incompatible with the objectives of the fund, as they may be harmful to society and/or inconsistent with the achievement of the UN Social Development Goals. Therefore the Fund does not invest in companies that derive any revenue from the production of tobacco, the manufacture of nicotine alternatives and tobacco based products, and controversial weapons production, including nuclear weapons. It does not support companies which generate more than 10% of their revenues (cumulative) from the production of alcohol, pornography, gambling, controversial fuels such as uranium, the extraction, production and electricity production from fossil fuels, old growth forest logging and non-RSPO palm oil or from gold mining, where Gold is the primary purpose of the mine. As well as factory farming, animals in entertainment, live exports and animal testing for cosmetic products, as well as other activities which are associated with animal welfare concerns. For healthcare, it tolerates testing only where necessary.

Alphinity seeks to invest in companies which can have a net positive alignment with one or more of the 17 United Nations Sustainable Development Goals (SDGs), and exceed Alphinity's minimum ESG criteria. A company's alignment with the SDGs is assessed using an in-house assessment methodology. This methodology aligns the positive and negative contributions that the company's products and services make towards the SDGs to arrive at a net score. Alphinity favours companies that are actively involved in initiatives aimed at making a positive impact across various sectors. These include enhancing food security, improving nutrition, and promoting sustainable agriculture to combat poverty; fostering healthier lives and well-being for individuals of all ages; ensuring inclusive and equitable quality education; championing gender equality and diversity; and supporting the development of sustainable cities and human settlements. Furthermore, Alphinity favours companies that contribute to sustained, inclusive, and sustainable economic growth, offering full and decent employment; building resilient infrastructure and promoting sustainable industrialisation; advocating for sustainable consumption and production patterns; combating climate change and its impacts; advancing affordable, reliable, and sustainable energy production; conserving biodiversity, forests, rivers, and oceans sustainably; and ensuring the sustainable management of water and sanitation.

Alphinity, a signatory to the United Nations-backed Principles for Responsible Investment (PRI) since 2011, is actively involved in various sustainability initiatives. As official supporters of the Task Force on Climate-Related Financial Disclosures (TCFD), members of the Responsible Investment Association of Australia (RIAA), and the Investor Group on Climate Change, Alphinity demonstrates its commitment to environmental, social, and governance (ESG) principles. Subscribing to external ESG research providers, the company closely monitors compliance with the UN Global Compact and controversies related to human rights violations. Alphinity champions the United Nations Guiding Principles on Business and Human Rights, expecting the same commitment from its investee companies. The firm encourages adherence to the TCFD recommendations, recognises the Intergovernmental Panel on Climate Change's findings, supports the United Nations Paris Agreement, and aims to invest in companies that align positively with the United Nations Sustainable Development Goals (SDGs), underscoring its dedication to sustainable investment.